{"id":54,"date":"2022-03-16T14:08:46","date_gmt":"2022-03-16T14:08:46","guid":{"rendered":"http:\/\/lengefeldlab.com\/?page_id=54"},"modified":"2023-07-05T14:37:38","modified_gmt":"2023-07-05T14:37:38","slug":"research","status":"publish","type":"page","link":"https:\/\/lengefeldlab.com\/?page_id=54","title":{"rendered":"Research"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"54\" class=\"elementor elementor-54\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b95b88e elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"b95b88e\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-31d9cc7\" data-id=\"31d9cc7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5d66876 elementor-widget elementor-widget-image\" data-id=\"5d66876\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1350\" height=\"1600\" src=\"https:\/\/lengefeldlab.com\/wp-content\/uploads\/2022\/07\/research_main-scaled-e1658953570817.jpg\" class=\"attachment-full size-full wp-image-963\" alt=\"\" srcset=\"https:\/\/lengefeldlab.com\/wp-content\/uploads\/2022\/07\/research_main-scaled-e1658953570817.jpg 1350w, https:\/\/lengefeldlab.com\/wp-content\/uploads\/2022\/07\/research_main-scaled-e1658953570817-253x300.jpg 253w, https:\/\/lengefeldlab.com\/wp-content\/uploads\/2022\/07\/research_main-scaled-e1658953570817-864x1024.jpg 864w, https:\/\/lengefeldlab.com\/wp-content\/uploads\/2022\/07\/research_main-scaled-e1658953570817-768x910.jpg 768w, https:\/\/lengefeldlab.com\/wp-content\/uploads\/2022\/07\/research_main-scaled-e1658953570817-1296x1536.jpg 1296w\" sizes=\"(max-width: 1350px) 100vw, 1350px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-6a93b74\" data-id=\"6a93b74\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-056d35e elementor-widget elementor-widget-heading\" data-id=\"056d35e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Our Research Interest<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-95cdfb0 elementor-widget elementor-widget-text-editor\" data-id=\"95cdfb0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>The failure to regenerate tissues during aging due to loss of stem cell function causes major health problems. However, it is still unclear how stem cells fail to maintain their functions during aging and disease.<\/p><p>We discovered a new aspect of stem cell aging in vivo: cellular enlargement. We found that stem cells increase in size during aging and that this is causing their functional decline.<\/p><p>However, we are only beginning to understand how size impacts stem cell fitness and the physiological importance of this process remains unsolved.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-78866a3 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"78866a3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-65407cb\" data-id=\"65407cb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-15a4981 elementor-widget elementor-widget-image\" data-id=\"15a4981\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1427\" height=\"1030\" src=\"https:\/\/lengefeldlab.com\/wp-content\/uploads\/2023\/07\/ERC-StG-interview_2023_1-scaled-e1688567810580.jpg\" class=\"attachment-full size-full wp-image-1400\" alt=\"\" srcset=\"https:\/\/lengefeldlab.com\/wp-content\/uploads\/2023\/07\/ERC-StG-interview_2023_1-scaled-e1688567810580.jpg 1427w, https:\/\/lengefeldlab.com\/wp-content\/uploads\/2023\/07\/ERC-StG-interview_2023_1-scaled-e1688567810580-300x217.jpg 300w, https:\/\/lengefeldlab.com\/wp-content\/uploads\/2023\/07\/ERC-StG-interview_2023_1-scaled-e1688567810580-1024x739.jpg 1024w, https:\/\/lengefeldlab.com\/wp-content\/uploads\/2023\/07\/ERC-StG-interview_2023_1-scaled-e1688567810580-768x554.jpg 768w\" sizes=\"(max-width: 1427px) 100vw, 1427px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-71a7a40\" data-id=\"71a7a40\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8eed81d elementor-widget elementor-widget-heading\" data-id=\"8eed81d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Our Research areas<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7147491 elementor-widget elementor-widget-heading\" data-id=\"7147491\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The three key questions:<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc73028 elementor-widget elementor-widget-text-editor\" data-id=\"bc73028\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>How does stem cell enlargement drive their dysfunction?<br \/><\/strong>We use molecular profiling and mouse models to identify the molecular mechanisms impairing fitness of large stem cells focusing particularly on metabolism.<\/p><p>\u00a0<\/p><p><strong>Can we rejuvenate stem cells by modulating their size?<\/strong><\/p><p>We aim to identify ways to rejuvenate stem cells by affecting their size. The goal of this project is to find ways how to improve stem cell function during aging and in disease.<\/p><p>\u00a0<\/p><p><strong>Does dysregulation of stem cell size promote<\/strong><strong> cancer?\u00a0<\/strong><\/p><p>We utilize blood stem cells from mice and humans to identify factors that facilitate leukemia\u00a0<em>in vivo<\/em>\u00a0and to investigate the underlying mechanisms.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-416eddd elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"416eddd\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-70a94e6\" data-id=\"70a94e6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-90786b2 elementor-widget elementor-widget-image\" data-id=\"90786b2\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"327\" height=\"79\" src=\"https:\/\/lengefeldlab.com\/wp-content\/uploads\/2022\/03\/metastem_tunnus_0.png\" class=\"attachment-large size-large wp-image-224\" alt=\"\" srcset=\"https:\/\/lengefeldlab.com\/wp-content\/uploads\/2022\/03\/metastem_tunnus_0.png 327w, https:\/\/lengefeldlab.com\/wp-content\/uploads\/2022\/03\/metastem_tunnus_0-300x72.png 300w\" sizes=\"(max-width: 327px) 100vw, 327px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a6e2056\" data-id=\"a6e2056\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9228d06 elementor-widget elementor-widget-button\" data-id=\"9228d06\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www2.helsinki.fi\/en\/researchgroups\/centre-of-excellence-in-stem-cell-metabolism\/research\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Metastem Official Website<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef4985b elementor-widget elementor-widget-text-editor\" data-id=\"ef4985b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The Lengefeld lab is now part of the Academy of Finland funded Centre of Excellence in Stem Cell Metabolism<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c558814 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c558814\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-0266dce\" data-id=\"0266dce\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6ed03e7 elementor-widget elementor-widget-video\" data-id=\"6ed03e7\" data-element_type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=Oc537Jk3RxM&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! 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However, it is still unclear how stem cells fail to maintain their functions during aging and disease. We discovered a new aspect of stem cell aging in vivo: cellular enlargement. We found that stem [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_canvas","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-54","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/lengefeldlab.com\/index.php?rest_route=\/wp\/v2\/pages\/54","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lengefeldlab.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lengefeldlab.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lengefeldlab.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lengefeldlab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=54"}],"version-history":[{"count":66,"href":"https:\/\/lengefeldlab.com\/index.php?rest_route=\/wp\/v2\/pages\/54\/revisions"}],"predecessor-version":[{"id":1840,"href":"https:\/\/lengefeldlab.com\/index.php?rest_route=\/wp\/v2\/pages\/54\/revisions\/1840"}],"wp:attachment":[{"href":"https:\/\/lengefeldlab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=54"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}